Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
نویسندگان
چکیده
منابع مشابه
Intracellular soluble α‐synuclein oligomers reduce pyramidal cell excitability
KEY POINTS The presynaptic protein α-synuclein forms aggregates during Parkinson's disease. Accumulating evidence suggests that the small soluble oligomers of α-synuclein are more toxic than the larger aggregates appearing later in the disease. The link between oligomer toxicity and structure still remains unclear. In the present study, we have produced two structurally-defined oligomers that h...
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Mutations, duplication and triplication of α-synuclein genes are linked to familial Parkinson's disease (PD), and aggregation of α-synuclein (α-syn) in Lewy bodies (LB) is involved in the pathogenesis of the disease. The targeted overexpression of α-syn in the substantia nigra (SN) mediated by viral vectors may provide a better alternative to recapitulate the neurodegenerative features of PD. T...
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The subcellular localization 46100 Burjasot of the synucleins has not been established definitively, Spain and suggested sites of action include the presynaptic 3 Although its physiological activity remains unclear, Summary ␣-Syn has been implicated in the etiology of two common neurodegenerative disorders, Alzheimer's disease ␣-Synuclein (␣-Syn) is a 14 kDa protein of unknown (AD) and Parkinso...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2017
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.4641